Splenomegaly after intensive treatment of hemophilia [letter]

Splenomegaly after intensive treatment of hemophilia.

The article by Levine et al.1 concerning abnormal liver chemistries and splenomegaly in intensively treated hemophiliacs left both observations unexplained. Although their literature search “revealed no reports of splenomegaly associated with hemophilia,” I would like to call attention to a 1966 report from our clinic on therapy of hemophilia with fraction I in which splenomegaly was observed a...

Relapses after withdrawal of proguanil treatment in tropical splenomegaly syndrome.

After the remission of symptoms and reduction in spleen size while on proguanil therapy four patients with the tropical splenomegaly syndrome defaulted from treatment. The withdrawal of proguanil caused a recrudescence of original symptoms, splenomegaly, and a return of the initially raised serum IgM. Complete return to normal values was again effected with proguanil therapy.The role of the spl...

Rituximab for Treatment of Hemophilia A with High-Responder Inhibitors

Background: The development of inhibitors is a complication factor replacement therapy in hereditary factor VIII deficiency. Several management options are available for the treatment of inhibitor. Rituximab, a monoclonal antibody against CD20, reduces inhibitor level in rare bleeding disorders. The aim of this study was to evaluate the effectiveness of rituximab in lowering or eliminating the ...

Pedunculine. (For Treatment of Bengal Splenomegaly)

etiology, significance, diagnosis and treatment of bruxiam

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